The Differential

Clinical reads on small-cap hem/onc catalysts.

Sent when there's something worth saying, not on a schedule. Each post carries a differential — a quick clinical-signal / regulatory-path / balance-sheet read — so you know what kind of piece you're getting before you read it.

Aug 2026

SELLAS's GPS bet: mature biology, a stronger balance sheet, and an unanswered Phase 3 question

A base-rate check on SELLAS's WT1-directed vaccine — and a question about where galinpepimut-S may ultimately fit in the AML treatment landscape.

Clinical signalEncouraging, unproven
Reg. pathPhase 3, event-driven
Balance sheetStrong
Aug 2026

Three small-cap AML plays racing toward pivotal readouts

SELLAS, Actinium, and Moleculin all have hematologic-malignancy assets nearing Phase 3 events — but only one of them can fund its way to the finish line without diluting hard.

Clinical signalStrong
Reg. pathModerate
Balance sheetMixed
Jul 2026

What a Breakthrough Therapy designation actually buys you

Investors treat BTD as a stamp of approval. It isn't one — it's a faster meeting schedule. Here's what changes and what doesn't for a confirmatory trial.

Clinical signalStrong
Reg. pathClear
Balance sheetWatch
Jul 2026

Reading an event-driven Phase 3: what "78 of 80" actually tells you

Event-driven survival trials report progress in a way that looks precise and is almost entirely uninformative about the result. A field guide for the non-clinician.

Clinical signalN/A
Reg. pathExplainer
Balance sheetN/A
Jun 2026

Deferred license revenue isn't debt — but the balance sheet doesn't say that

A non-cash liability tied to an ex-U.S. licensing deal can make a company's balance sheet look far more distressed than it is. How to tell the difference in five minutes.

Clinical signalN/A
Reg. pathN/A
Balance sheetExplainer

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